2. Academic Validation
  3. The recent progress of isoxazole in medicinal chemistry

The recent progress of isoxazole in medicinal chemistry

  • Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. doi: 10.1016/j.bmc.2018.05.013.
Jie Zhu 1,  Jun Mo 1,  Hong-Zhi Lin 1,  Yao Chen 2,  Hao-Peng Sun 3
Affiliations

Affiliations

  • 1 Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
  • 2 Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • 3 Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: [email protected].
PMID: 29853341 DOI: 10.1016/j.bmc.2018.05.013
Abstract

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design. In this review article, the major focus has been paid to the applications of isoxazole compounds in treating multiple diseases, including Anticancer, antimicrobial, anti-inflammatory, etc. Strategies for compounds design for preclinical, clinical, and FDA approved drugs were discussed. Also, the emphasis has been addressed to the future perspectives and trend for the application.

Keywords

Anti-inflammation; Anticancer; Antimicrobial; Biological activities; Isoxazole.

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