1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    E1/E2/E3 Enzyme
  3. N106

N106 

Cat. No.: HY-110273
Handling Instructions

N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research.

For research use only. We do not sell to patients.

N106 Chemical Structure

N106 Chemical Structure

CAS No. : 862974-25-2

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Description

N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research[1].

In Vitro

N106 treatment increases contractile properties of cultured rat cardiomyocytes. N106 increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation within 10 min of exposure, and these effects are sustained at 24 h in cardiomyocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a murine model, the half-life of N106 is determined to be ∼65.4 min with a Cmax of ∼2.24 μM when the mice received 10 mg/kg of N106 by intravenous injection. The oral bioavailability (F%) is 56% and 50%, and terminal elimination half-life (t1/2) is 19 min[1].
In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation, and significantly improves ventricular function in mice with heart failure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.38

Formula

C17H14N4O3S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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