1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. COMT
  3. Nitecapone

Nitecapone (Synonyms: OR-462)

Cat. No.: HY-106842
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Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.

For research use only. We do not sell to patients.

Nitecapone Chemical Structure

Nitecapone Chemical Structure

CAS No. : 116313-94-1

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5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].

In Vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%[1].

In Vivo

Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats[3].

Animal Model: Eighty-six male Wistar rats, weighing 140-350 g[3].
Dosage: 30 mg/kg (3.3 mL/kg).
Administration: IP, once daily for 13 days.
Result: Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.
Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.
Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
Molecular Weight

265.22

Formula

C₁₂H₁₁NO₆

CAS No.

116313-94-1

SMILES

CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NitecaponeOR-462OR462OR 462COMTCatechol-O-methyltransferaseglutathioneallodyniaGSHROSParkinsonInhibitorinhibitorinhibit

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