2. Metabolic Enzyme/Protease
    Neuronal Signaling
  3. COMT
  4. Nitecapone

Nitecapone  (Synonyms: OR-462)

Cat. No.: HY-106842 Purity: 99.53%
COA Handling Instructions

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.

For research use only. We do not sell to patients.

Nitecapone Chemical Structure

Nitecapone Chemical Structure

CAS No. : 116313-94-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 231 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 231 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].

In Vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty-six male Wistar rats, weighing 140-350 g[3].
Dosage: 30 mg/kg (3.3 mL/kg).
Administration: IP, once daily for 13 days.
Result: Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.
Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.
Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
Molecular Weight

265.22

Appearance

Solid

Formula

C12H11NO6
CAS No.
SMILES

CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (188.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7705 mL 18.8523 mL 37.7045 mL
5 mM 0.7541 mL 3.7705 mL 7.5409 mL
10 mM 0.3770 mL 1.8852 mL 3.7705 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.53%

COA (253 KB) HNMR (273 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Nitecapone116313-94-1OR-462OR462OR 462COMTCatechol-O-methyltransferaseglutathioneallodyniaGSHROSParkinsonInhibitorinhibitorinhibit

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