116313-94-1
116313-94-1
Chemical Structure
Nitecapone
Synonym(s): OR-462
- CAS No.: 116313-94-1
- Formula:C12H11NO6
- Molecular Weight:265.22
IUPAC Name: 3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,4-dione
InChIKey: UPMRZALMHVUCIN-UHFFFAOYSA-N
SMILES: CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O
Biological Activity: Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nitecapone | 98.71% | Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation. | ||||||||||||||||||||
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References
- [1]. Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462). Free Radic Biol Med. 1992 Nov;13(5):517-25. [Content Brief]
- [2]. Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34(3):531-541.
- [3]. Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15(7):732-40. [Content Brief]
