2,2'-Bipyridine
Based on 1 publication(s) in Google Scholar
2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 366-18-7
- Formula: C10H8N2
- Molecular Weight:156.19
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) 2,2'-Bipyridine
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Customer Validation & Images
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Microbiological Assay
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>20 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
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[PMID: 11931621] |
| A2780 | IC50 |
44.8 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
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[PMID: 11931621] |
| CCRF-CEM | IC50 |
51.9 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
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[PMID: 11931621] |
| CCRF-CEM | IC50 |
61.7 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
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[PMID: 11931621] |
| COS-7 | EC50 |
19 μM
Compound: Bip
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Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | EC50 |
34 μM
Compound: Bip
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Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | EC50 |
42 μM
Compound: Bip
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Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | IC50 |
126 μM
Compound: Bip
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Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
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[PMID: 22957890] |
| COS-7 | IC50 |
84 μM
Compound: Bip
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Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
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[PMID: 22957890] |
| HUVEC | EC50 |
10 μM
Compound: 2,2'-bipyridine
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Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
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[PMID: 23634668] |
| SK-OV-3 | IC50 |
41.3 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
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[PMID: 11931621] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Holtzman rats (6-8 weeks old)[2].
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Dosage:40 mg/kg
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Administration:Subcutaneous injection; once.
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Result:Showed hyperglycemic activity.
Chemical Information
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CAS No. 366-18-7
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Appearance Solid
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Molecular Weight 156.19
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Formula C10H8N2
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Color White to light yellow
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SMILES
C1(C2=NC=CC=C2)=NC=CC=C1
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Synonyms
2,2'-Dipyridyl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Photochem Photobiol B
Antimicrobial blue light inactivation of Pseudomonas aeruginosa: Unraveling the multifaceted impact of wavelength, growth stage, and medium composition. [Abstract]2024 Oct:259:113023. PMID: 39241393
2,2'-Bipyridine purchased from MedChemExpress. Usage Cited in: J Photochem Photobiol B. 2024 Oct:259:113023. [Abstract]
Modulation of PAO1 sensitivity to 405 nm aBL in BHI medium with or without FeCl3 supplementation in the presence of the iron chelator 2,2'-Bipyridine (BIP) (500 μM).
Solvent & Solubility
DMSO : 100 mg/mL (640.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4025 mL | 32.0123 mL | 64.0246 mL | 160.0615 mL |
| 5 mM | 1.2805 mL | 6.4025 mL | 12.8049 mL | 32.0123 mL | |
| 10 mM | 0.6402 mL | 3.2012 mL | 6.4025 mL | 16.0061 mL | |
| 15 mM | 0.4268 mL | 2.1342 mL | 4.2683 mL | 10.6708 mL | |
| 20 mM | 0.3201 mL | 1.6006 mL | 3.2012 mL | 8.0031 mL | |
| 25 mM | 0.2561 mL | 1.2805 mL | 2.5610 mL | 6.4025 mL | |
| 30 mM | 0.2134 mL | 1.0671 mL | 2.1342 mL | 5.3354 mL | |
| 40 mM | 0.1601 mL | 0.8003 mL | 1.6006 mL | 4.0015 mL | |
| 50 mM | 0.1280 mL | 0.6402 mL | 1.2805 mL | 3.2012 mL | |
| 60 mM | 0.1067 mL | 0.5335 mL | 1.0671 mL | 2.6677 mL | |
| 80 mM | 0.0800 mL | 0.4002 mL | 0.8003 mL | 2.0008 mL | |
| 100 mM | 0.0640 mL | 0.3201 mL | 0.6402 mL | 1.6006 mL |
2,2'-Bipyridine Related Classifications
HY-D0020 Related Classifications
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