CASP8 - caspase 8 Gene

Also Known as CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 841

About CASP8

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,233,443-201,287,711 (from NCBI)

This gene has 25 transcripts (splice variants), 132 orthologues, 16 paralogues and is associated with 100 phenotypes. Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

CASP8 Products (72)

mRNA	Protein	Name
NM_001400653.1	NP_001387582.1	caspase-8 isoform 2 precursor
NM_001228.4	NP_001219.2	caspase-8 isoform 1 precursor
NR_174584.1
NM_001080124.2	NP_001073593.1	caspase-8 isoform 3
NM_001372051.1	NP_001358980.1	caspase-8 isoform 2 precursor
NM_001400678.1	NP_001387607.1	caspase-8 isoform 18
NM_001400680.1	NP_001387609.1	caspase-8 isoform 17
NR_174588.1
NM_001400673.1	NP_001387602.1	caspase-8 isoform 16
NM_001400668.1	NP_001387597.1	caspase-8 isoform 13
NR_174589.1
NM_001400679.1	NP_001387608.1	caspase-8 isoform 5
NM_001400675.1	NP_001387604.1	caspase-8 isoform 18
NM_001400672.1	NP_001387601.1	caspase-8 isoform 16
NR_174565.1
NM_001400662.1	NP_001387591.1	caspase-8 isoform 3
NR_174585.1
NR_174591.1
NM_033356.4	NP_203520.1	caspase-8 isoform 3
NR_174592.1
NR_174564.1
NM_001400664.1	NP_001387593.1	caspase-8 isoform 10
NR_174581.1
NM_001400654.1	NP_001387583.1	caspase-8 isoform 2 precursor
NM_001400655.1	NP_001387584.1	caspase-8 isoform 2 precursor
NM_001400751.1	NP_001387680.1	caspase-8 isoform 18
NR_174583.1
XM_011511969.3	XP_011510271.1	caspase-8 isoform X3
NM_033355.3	NP_203519.1	caspase-8 isoform 2 precursor
NM_033357.2
NM_001400670.1	NP_001387599.1	caspase-8 isoform 15
NR_174595.1
NR_174598.1
NM_001400663.1	NP_001387592.1	caspase-8 isoform 3
NR_111983.2
NM_001400677.1	NP_001387606.1	caspase-8 isoform 18
NR_174596.1
NM_001400657.1	NP_001387586.1	caspase-8 isoform 2 precursor
NM_001400661.1	NP_001387590.1	caspase-8 isoform 3
NM_001400658.1	NP_001387587.1	caspase-8 isoform 3
NR_174594.1
XR_007082539.1
XM_005246893.4	XP_005246950.1	caspase-8 isoform X4
NM_001400660.1	NP_001387589.1	caspase-8 isoform 3
NM_001400669.1	NP_001387598.1	caspase-8 isoform 14
NR_174582.1
NM_001400645.1	NP_001387574.1	caspase-8 isoform 9
NM_001400676.1	NP_001387605.1	caspase-8 isoform 18
NR_174602.1
NM_001400651.1	NP_001387580.1	caspase-8 isoform 2 precursor
NR_174586.1
NR_174590.1
NR_174593.1
NM_001400659.1	NP_001387588.1	caspase-8 isoform 3
NM_001400750.1	NP_001387679.1	caspase-8 isoform 16
NM_001400665.1	NP_001387594.1	caspase-8 isoform 11
NM_001080125.2	NP_001073594.1	caspase-8 isoform 7 precursor
NM_001400666.1	NP_001387595.1	caspase-8 isoform 12
NM_001400671.1	NP_001387600.1	caspase-8 isoform 16
XM_047445959.1	XP_047301915.1	caspase-8 isoform X1
NM_001400667.1	NP_001387596.1	caspase-8 isoform 13
NM_001400642.1	NP_001387571.1	caspase-8 isoform 8
NR_174601.1
XM_047445961.1	XP_047301917.1	caspase-8 isoform X5
NR_174599.1
NM_033358.4
NM_001400648.1	NP_001387577.1	caspase-8 isoform 2 precursor
XM_047445960.1	XP_047301916.1	caspase-8 isoform X2
NM_001400674.1	NP_001387603.1	caspase-8 isoform 17
XR_007082538.1
NM_001400656.1	NP_001387585.1	caspase-8 isoform 2 precursor
NR_174600.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16920334	GOA
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16916640	GOA
enables cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16916640	GOA
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11717445	GOA
enables death effector domain binding	IPI IPI: Inferred from physical interaction	11717445	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	19740745	GOA
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	17047155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8681376	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	21785459	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15069192	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in TRAIL-activated apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21785459	GOA
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22891283	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11101870	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21785459	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	9184224	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17047155	GOA
involved in negative regulation of necroptotic process	IDA IDA: Inferred from direct assay	31827280	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12884866	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	18216014	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	17047155	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	16916640	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	12888622	GOA
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	10521396	GOA
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	10521396	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	11717445	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	17167422	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17167422	GOA
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	11101870	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	18216014	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22267217	GOA
part of ripoptosome	IDA IDA: Inferred from direct assay	21737330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP8 Protein Structure

DED

Peptidase_C14

0
100
200
300
400
500
538 a.a.

Protein Preferred Names	Protein Names
caspase-8	FADD-homologous ICE/CED-3-like protease FADD-like ICE ICE-like apoptotic protease 5 MACH-alpha-1/2/3 protein MACH-beta-1/2/3/4 protein MORT1-associated ced-3 homolog apoptotic cysteine protease apoptotic protease Mch-5 caspase 8, apoptosis-related cysteine peptidase caspase 8, apoptosis-related cysteine protease

CASP8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASP8	Q14790	MALT1	Homo sapiens	Q9UDY8	Anti Bait CoIP	22267217
Intra	CASP8	Q14790	CASP8AP2	Homo sapiens	Q9UKL3	CoIP	10235259
Intra	CASP8	Q14790	CASP8AP2	Homo sapiens	Q9UKL3	Y2H	10235259
Intra	CASP8	Q14790	CASP8AP2	Homo sapiens	Q9UKL3	Imaging	17245429
Intra	CASP8	Q14790	RNF34	Homo sapiens	Q969K3	Anti Tag CoIP	15069192
Intra	CASP8	Q14790	RNF34	Homo sapiens	Q969K3	Y2H	15069192
Intra	CASP8	Q14790	VPS33A	Homo sapiens	Q96AX1	Y2H Array	32814053
Intra	CASP8	Q14790	VPS33A	Homo sapiens	Q96AX1	Y2H Pooling	32814053
Intra	CASP8	Q14790	VPS33A	Homo sapiens	Q96AX1	Validated Y2H	32814053
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	19060883
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	19524513
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	21525013
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	19524512
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22173242
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	12887920
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	23955153
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	21458669
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	18485876
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Pull Down	12884866
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22274400
Intra	CASP8	Q14790	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	25911380
Intra	CASP8	Q14790	CUL3	Homo sapiens	Q13618	Anti Bait CoIP	19427028
Intra	CASP8	Q14790	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	19427028
Intra	CASP8	Q14790	CFLAR	Homo sapiens	O15519-1	Anti Bait CoIP	17159907
Intra	CASP8	Q14790	CFLAR	Homo sapiens	O15519-1	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	FAS	Homo sapiens	P25445	Anti Bait CoIP	18328427
Intra	CASP8	Q14790	FAS	Homo sapiens	P25445	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	FAS	Homo sapiens	P25445	Anti Bait CoIP	12887920
Intra	CASP8	Q14790	FAS	Homo sapiens	P25445	Density Sedimentation	17159907
Intra	CASP8	Q14790	FAS	Homo sapiens	P25445	Anti Bait CoIP	17159907
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	19524512
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	19060883
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Density Sedimentation	17159907
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	21458669
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	12887920
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Tag CoIP	21785459
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	18485876
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	17159907
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	14612908
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	20103630
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	Anti Bait CoIP	21525013
Intra	CASP8	Q14790	FADD	Homo sapiens	Q13158	FRET	11717445
Intra	CASP8	Q14790	CASP10	Homo sapiens	Q92851	Anti Bait CoIP	12887920
Intra	CASP8	Q14790	CASP10	Homo sapiens	Q92851	Anti Bait CoIP	17159907
Intra	CASP8	Q14790	CFLAR	Homo sapiens	O15519	Anti Bait CoIP	24438025
Intra	CASP8	Q14790	CFLAR	Homo sapiens	O15519	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	CFLAR	Homo sapiens	O15519	Anti Bait CoIP	12887920
Intra	CASP8	Q14790	TNFRSF10A	Homo sapiens	O00220	Confocal	19427028
Intra	CASP8	Q14790	TNFRSF10A	Homo sapiens	O00220	Anti Bait CoIP	17047155
Intra	CASP8	Q14790	TNFRSF10A	Homo sapiens	O00220	Anti Bait CoIP	20103630
Intra	CASP8	Q14790	TNFAIP3	Homo sapiens	P21580	Anti Bait CoIP	19060883
Intra	CASP8	Q14790	AR	Homo sapiens	P10275	Pull Down	17170703
Intra	CASP8	Q14790	ILK	Homo sapiens	Q13418	Anti Bait CoIP	16936772
Intra	CASP8	Q14790	BCAP31	Homo sapiens	P51572	CoIP	9334338
Intra	CASP8	Q14790	BCAP31	Homo sapiens	P51572	Anti Bait CoIP	21183955

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CASP8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71708	Caspase-8/CASP8 subunit p18 Protein, Human (His)	Q14790 (S217-D374)	≥ 90%, as determined by reducing SDS-PAGE.

CASP8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80049	Caspase-8 Antibody (YA554)	WB, ICC/IF, IHC-P	Human
HY-P80624	Cleaved-Caspase 8 Antibody (YA792)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80624A	Cleaved-Caspase 8 Antibody (YA792)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84575	Caspase-8 Antibody (YA4272)	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P84575A	Caspase-8 Antibody (YA4272)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey, Rat
HY-P85727	Caspase-8 Antibody (YA5419)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P86141	Caspase-8 Antibody (YA5833)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Brain Glioblastoma Multiforme	Brain Glioblastoma Glioblastoma Multiforme Of Brain Glioblastoma Nos
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Autonomic Nervous System Neoplasm	Tumor Of Autonomic Nervous System
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Kaposi'S Sarcoma-Associated Herpesvirus Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Rhabdomyosarcoma
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Adult Hepatocellular Carcinoma	Adult Primary Hepatocellular Carcinoma Adult Hepatoma Adult Hcc
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Tendinopathy
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Caspase 8 Deficiency	Autoimmune Lymphoproliferative Syndrome Type 2b Ceds Alps2b Caspase-8 Deficiency Autoimmune Lymphoproliferative Syndrome, Type Iib Alps With Recurrent Viral Infections Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections Caspase 8 Deficiency Syndrome Autoimmune Lymphoproliferative Syndrome Type Iib Caspase Eight Deficiency State CASP8D
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Clubfoot	Congenital Clubfoot Congenital Equinovarus Congenital Talipes Equinovarus Equinovarus Deformity Of Foot Club Foot
Uterine Corpus Endometrial Carcinoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Pneumoconiosis	Pneumoconioses Silicosis Nos Complicated Silicosis Fibrosis Of Lung With Silicosis Nodular Silicosis Pneumoconiosis Due To Silica Silicotic Fibrosis Of Lung Simple Silicosis Silicatosis Silicotic Lung Fibrosis Pneumoconiosis Due To Talc Pulmonary Talcosis Talc Lung Disease Talc Pneumoconiosis Talc Workers' Pneumoconiosis Talcosis Fibrosis Of Lung Due To Talc Asbestos Pneumoconiosis Amianthosis Asbestosis Lung Fibrosis With Asbestosis Pulmonary Asbestosis
Cowpox	Yaba
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153161	CASP8-IN-1	Inhibitor	98.97%	Unkown
HY-P10146	Ac-LETD-CHO	Inhibitor	/	Unkown
HY-RS01965	CASP8 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01966	Casp8 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01967	Casp8 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CASP8	VGNC	VGNC:26784
Felis catus	CASP8	VGNC	VGNC:60384
Mus musculus	CASP8	MGD	MGI:1261423
Canis familiaris	CASP8	VGNC	VGNC:38736
Macaca mulatta	CASP8	VGNC	VGNC:70547
Rattus norvegicus	CASP8	RGD	RGD:620945
Others	CASP8	NCBI