Partricin A
Partricin A is an antimicrobial agent with affinity for ergosterol and cholesterol. Partricin A inhibits growth of fungal species and Trichomonas vaginalis. Partricin A induces hemolysis of rat erythrocytes. Partricin A causes acute toxicity in mice via intraperitoneal or intravenous administration. Partricin A serves as a starting material for synthesis of semisynthetic amide derivatives. Partricin A can be used for the research of fungal infections, trichomonas vaginalis infection.
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- CAS No.: 76551-64-9
- 화학식: C59H86N2O19
- 분자량:1127.32
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Biological Activity
Partricin A (serial dilutions; 24-48 h) inhibits growth of Candida albicans strains LRM 73, LRM 200, and LRM 205 with minimum inhibitory concentrations ranging from 30 ng/mL (24 h, LB) to 120 ng/mL (48 h, SB)[1].
Partricin A (serial dilutions; 7 h) inhibits 50% of Saccharomyces cerevisiae LRM 167 growth with an IC50 of 2.1 ng/mL after 7 h incubation in liquid medium[1].
Partricin A (serial dilutions; 24-48 h, 4 days, 5 days) inhibits growth of Mucor sp. LRM 263 (MIC 1.2-2.4 μg/mL), Aspergillus niger LRM 374 (MIC 2.4 μg/mL), and Trichophyton mentagrophytes LRM 176 (MIC 2.4 μg/mL) in solid or liquid culture media[1].
Partricin A (serial dilutions; 48 h) inhibits growth of Trichomonas vaginalis LRM 415 with an MIC of 0.075 μg/mL after 48 h incubation in semisolid medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (male, 4-5 weeks old, 14-18 g)[1]
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Dosage:0.6 mg/kg
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Administration:i.p.
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Result:Exhibited an intraperitoneal LD50 of 0.6 mg/kg.
Chemical Information
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CAS No. 76551-64-9
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분자량 1127.32
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화학식 C59H86N2O19
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SMILES
O=C(O[C@H]([C@@H](C)CC[C@@H](O)CC(C1=CC=C(NC)C=C1)=O)[C@@H](C)/C=C/C=C/C=C\C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C3)C[C@H](O)CC(C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@]4(O)C[C@H](O)[C@@H](C(O)=O)[C@H]3O4)=O
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Structure Classification
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Initial Source
Streptomyces aureofaciens
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Partricin A Related Classifications
HY-N21836 Related Classifications
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