2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Perfluoroenanthic acid

Perfluoroenanthic acid  (Synonyms: Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA)

Cat. No.: HY-21197 Purity: 98.0%
COA
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Handling Instructions Technical Support

Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue.

For research use only. We do not sell to patients.

Perfluoroenanthic acid

Perfluoroenanthic acid Chemical Structure

CAS No. : 375-85-9

Size Price Stock Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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1 g In-stock
5 g In-stock
10 g In-stock
50 g   Get quote  

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Other Forms of Perfluoroenanthic acid:

Perfluoroenanthic acid Related Antibodies

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  • Biological Activity

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Description

Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue[1][2][3].

In Vivo

Perfluoroenanthic acid (0.0015-0.15 mg/kg bw/d; oral gavage; daily; 16 days) induces reproductive toxicity in male offspring of C57BL/6 mice[1].
Perfluoroenanthic acid (1.25-5% (v/v); percutaneous administration; once daily; for 28 consecutive days) induces systemic toxicity in female B6C3F1 mice in a subchronic 28-day skin exposure model, including increased liver weight, altered immune cell phenotypes, hepatocyte hypertrophy, and dysregulated gene expression associated with the PPAR pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (female: 7 weeks old at breeding; male offspring: sacrificed at 7 weeks old; prenatal exposure reproductive toxicity model)[1]
Dosage: 0.0015 mg/kg bw/d; 0.015 mg/kg bw/d; 0.15 mg/kg bw/d
Administration: i.g.; daily; 16 days (GD1-GD16)
Result: Reduced sperm count and concentration.
Increased sperm progressive cells’ head area significantly in the 0.015 mg/kg bw/d group.
Caused slightly enlarged seminiferous tubule lumens in the 0.0015 mg/kg bw/d group.
Caused disordered seminiferous epithelium arrangement, reduced spermatogenic cell numbers, and enlarged tubule lumens in the 0.015 mg/kg bw/d group.
Caused severely disordered seminiferous epithelium, reduced spermatogenic cell layers, and shrunken seminiferous tubules in the 0.15 mg/kg bw/d group.
Decreased absolute m6A levels in testicular tissue.
Decreased Mettl3 and Mettl5 expression, and increased Mettl14 expression.
Decreased Pcif1 and Wtap expression, and increased Hnrnpa2b1 expression.
Molecular Weight

364.06

Formula

C7HF13O2
CAS No.
Appearance

<30°C Solid,>30°C Liquid

Color

Colorless to off-white

SMILES

O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (274.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7468 mL 13.7340 mL 27.4680 mL
5 mM 0.5494 mL 2.7468 mL 5.4936 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (13.73 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (13.73 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.0%

SDS (477 KB)

COA (247 KB) CNMR (275 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7468 mL 13.7340 mL 27.4680 mL 68.6700 mL
5 mM 0.5494 mL 2.7468 mL 5.4936 mL 13.7340 mL
10 mM 0.2747 mL 1.3734 mL 2.7468 mL 6.8670 mL
15 mM 0.1831 mL 0.9156 mL 1.8312 mL 4.5780 mL
20 mM 0.1373 mL 0.6867 mL 1.3734 mL 3.4335 mL
25 mM 0.1099 mL 0.5494 mL 1.0987 mL 2.7468 mL
30 mM 0.0916 mL 0.4578 mL 0.9156 mL 2.2890 mL
40 mM 0.0687 mL 0.3433 mL 0.6867 mL 1.7167 mL
50 mM 0.0549 mL 0.2747 mL 0.5494 mL 1.3734 mL
60 mM 0.0458 mL 0.2289 mL 0.4578 mL 1.1445 mL
80 mM 0.0343 mL 0.1717 mL 0.3433 mL 0.8584 mL
100 mM 0.0275 mL 0.1373 mL 0.2747 mL 0.6867 mL
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Perfluoroenanthic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perfluoroenanthic acid375-85-9Perfluoroheptanoic acid Tridecafluoroheptanoic acid PFHpAPPARPeroxisome proliferator-activated receptorsreproductive toxicityPPAR family receptorsm6A methyltransferasesC57BL/6 micecAMP/cGMP signalingtesticular tissue damagem6A RNA methylationB6C3F1 miceenvironmental endocrine disruptorm6A binding proteinsInhibitorinhibitorinhibit

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