2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis
  3. PROTACs c-Met/HGFR Apoptosis
  4. PRO-6E

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PRO-6E

PRO-6E 構造式

CAS 番号 : 2353493-69-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1244 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1244 在庫あり
Solid
5 mg $666 在庫あり
10 mg $1198 在庫あり
25 mg $2150 在庫あり
50 mg $3225 在庫あり
100 mg $4800 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

PRO-6E 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878))[1].

体外実験

PRO-6E (0.03-10 μM; 48 h) inhibits the cell growth in MKN-45, SNU-638 cells[1].
PRO‐6 E (1 μM; over 24 h) facilitates MET degradation in MKN-45 cells[1].
PRO‐6 E (0.1-1 μM; 48 h) increase in the percentage of G2/M phase cells and decrease in the percentage of S phase cells in MKN-45 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRO-6E 関連抗体

Cell Viability Assay[1]

Cell Line: MKN-45, SNU-638 cells
Concentration: 0, 0.03, 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 48 h
Result: Inhibited the cell growth.

Cell Cycle Analysis[1]

Cell Line: MKN-45 cells
Concentration: 0, 0.1, 0.3, 1, 3 μM
Incubation Time: 48 h
Result: Increased in the percentage of G2/M phase cells and decreased in the percentage of S phase cells.

Western Blot Analysis[1]

Cell Line: MKN-45 cells
Concentration: 0, 0.03, 0.1, 0.3, 1, 3 μM
Incubation Time: 12, 24, 36, 48, and 72 h
Result: facilitated MET degradation over 24 hours.
体内実験

PRO-6E (oral gavage; 30 mg/kg/day for 15 days) inhibits tumor growth in MKN‐45 cell‐derived xenograft tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MKN‐45 cell‐derived xenograft tumor model[1]
Dosage: 30 mg/kg/day for 15 days
Administration: Oral gavage
Result: Inhibited tumor growth.
分子量

848.75

分子式

C42H44Cl2FN7O7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (117.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1782 mL 5.8910 mL 11.7820 mL
5 mM 0.2356 mL 1.1782 mL 2.3564 mL
10 mM 0.1178 mL 0.5891 mL 1.1782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1782 mL 5.8910 mL 11.7820 mL 29.4551 mL
5 mM 0.2356 mL 1.1782 mL 2.3564 mL 5.8910 mL
10 mM 0.1178 mL 0.5891 mL 1.1782 mL 2.9455 mL
15 mM 0.0785 mL 0.3927 mL 0.7855 mL 1.9637 mL
20 mM 0.0589 mL 0.2946 mL 0.5891 mL 1.4728 mL
25 mM 0.0471 mL 0.2356 mL 0.4713 mL 1.1782 mL
30 mM 0.0393 mL 0.1964 mL 0.3927 mL 0.9818 mL
40 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7364 mL
50 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5891 mL
60 mM 0.0196 mL 0.0982 mL 0.1964 mL 0.4909 mL
80 mM 0.0147 mL 0.0736 mL 0.1473 mL 0.3682 mL
100 mM 0.0118 mL 0.0589 mL 0.1178 mL 0.2946 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PRO-6E Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRO-6E2353493-69-1PROTACsc-Met/HGFRApoptosisgastric cancerMKN-45SNU‐638cell apoptosisMKN‐45 cell‐derived xenograft tumor modelInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
PRO-6E
製品番号:
HY-160506
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.