2353493-69-1
Chemical Structure
PRO-6E
- CAS No.: 2353493-69-1
- Formula:C42H44Cl2FN7O7
- Molecular Weight:848.75
InChIKey: JSQFSAUVTNADLF-LZDHLTRGSA-N
SMILES: O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O
Biological Activity: PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878))[1].
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PRO-6E | 99.10% | PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)). | ||||||||||||||||||||
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Keywords
