Cytotoxic effect (on tumor cells) and in vitro antiviral activity against herpes simplex virus of synthetic spongiane diterpenes

  • J Nat Prod. 2002 Feb;65(2):189-92. doi: 10.1021/np010206t.
Liliana Betancur-Galvis  1 ,  Carmen Zuluaga ,  Manuel Arnó ,  Miguel A González ,  Ramón J Zaragozá
Affiliations
  • 1. Grupo Inmunovirología-Biogénesis, Universidad de Antioquia, A.A1226, Medellín, Colombia. [email protected]
PMID: 11858754 DOI: 10.1021/np010206t
Abstract

A series of synthetic spongiane-type diterpenes have been tested in vitro for their potential antitumor and antiherpetic activity. Although the Antiviral activity of these compounds against herpes simplex virus type 2 (HSV-2) was very weak, some compounds exhibited relevant cytotoxicity in the human tumor cell lines HeLa and HEp-2. The biological activity of formyl spongianes is reported for the first time. With the present study, some structure-activity trends are suggested for the cytotoxic activity of these sponge-derived natural products.