Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

  • Phytochemistry. 2005 Mar;66(6):627-32. doi: 10.1016/j.phytochem.2004.12.018.
Samira Benyahia  1 ,  Samir Benayache ,  Fadila Benayache ,  Francisco León ,  José Quintana ,  Matías López ,  Juan C Hernández ,  Francisco Estévez ,  Jaime Bermejo
Affiliations
  • 1. Laboratory of Valorisation of Natural Resources, University of Constantine, Constantine 25000, Algeria.
PMID: 15771880 DOI: 10.1016/j.phytochem.2004.12.018
Abstract

A formylated triterpene named cladocalol has been isolated from the leaves of Eucalyptus cladocalyx, together with ursulolactone acetate, ursolic acid, 3 beta-acetate-12,20(29)-lupadien-28-oic acid, beta-sitosterol and the known flavonoid eucalyptine. Their structures were mainly established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC) and mass spectroscopy as well as by X-ray crystallographic analysis. In this paper, we report on the cytotoxic effect induced by cladocalol and its derivatives on the myeloid leukemia cell line HL-60.

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