Secondary metabolites from Andrographis paniculata

  • Chem Pharm Bull (Tokyo). 2007 Mar;55(3):455-8. doi: 10.1248/cpb.55.455.
Wenkui Li  1 ,  Xudong Xu ,  Hongjie Zhang ,  Cuiying Ma ,  Harry Fong ,  Richard van Breemen ,  John Fitzloff
Affiliations
  • 1. Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago, IL 60612, USA.
PMID: 17329890 DOI: 10.1248/cpb.55.455
Abstract

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside (1) and 5-hydroxy-7,8,2',5'-tetramethoxy-flavone-5-O-beta-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 microg/ml, respectively.

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