Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense

  • J Nat Prod. 2009 Jun;72(6):1092-6. doi: 10.1021/np900021h.
Somyote Sutthivaiyakit  1 ,  Oracha Thongnak ,  Thitima Lhinhatrakool ,  Orapan Yodchun ,  Ratree Srimark ,  Prisana Dowtaisong ,  Mayuree Chuankamnerdkarn
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. [email protected]
PMID: 19555123 DOI: 10.1021/np900021h
Abstract

Eight new prenylated Flavonoids, khonklonginols A-H (1-8), together with six known compounds including five Flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1-8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.