Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides

  • J Nat Prod. 2010 Feb 26;73(2):167-71. doi: 10.1021/np900538r.
Wei-Hua Jiao  1 ,  Hao Gao ,  Chen-Yang Li ,  Feng Zhao ,  Ren-Wang Jiang ,  Ying Wang ,  Guang-Xiong Zhou ,  Xin-Sheng Yao
Affiliations
  • 1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
PMID: 20095629 DOI: 10.1021/np900538r
Abstract

Four new bis-beta-carboline Alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of the new compounds were determined on the basis of their 1D and 2D NMR and X-ray diffraction data. A possible biogenetic pathway for these Alkaloids was proposed, and all compounds were evaluated for anti-inflammatory activity. Only quassidine A (1) showed weak activity.