Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp

  • Bioorg Med Chem Lett. 2011 Oct 1;21(19):5715-8. doi: 10.1016/j.bmcl.2011.08.023.
Seong-Hwan Kim  1 ,  Hyeonseok Ko ,  Hea-Son Bang ,  Seon-Hui Park ,  Dong-Gyu Kim ,  Hak Cheol Kwon ,  Sun Yeou Kim ,  Jongheon Shin ,  Dong-Chan Oh
Affiliations
  • 1. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
PMID: 21873059 DOI: 10.1016/j.bmcl.2011.08.023
Abstract

Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.