Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia

  • J Nat Prod. 1990 Mar-Apr;53(2):456-8. doi: 10.1021/np50068a026.
G R Pettit  1 ,  A Numata ,  T Takemura ,  R H Ode ,  A S Narula ,  J M Schmidt ,  G M Cragg ,  C P Pase
Affiliations
  • 1. Cancer Research Institute, Arizona State University, Tempe 85287.
PMID: 2380718 DOI: 10.1021/np50068a026
Abstract

The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.