Trinorditerpenes from the roots of Flueggea virosa

  • Bioorg Med Chem Lett. 2014 Jan 15;24(2):447-9. doi: 10.1016/j.bmcl.2013.12.051.
Chih-Hua Chao  1 ,  Ju-Chien Cheng  2 ,  Tsong-Long Hwang  3 ,  De-Yang Shen  4 ,  Tian-Shung Wu  5
Affiliations
  • 1. School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: [email protected].
  • 2. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
  • 3. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
  • 4. Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
  • 5. Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: [email protected].
PMID: 24388689 DOI: 10.1016/j.bmcl.2013.12.051
Abstract

Two trinorditerpenes, flueggrenes A and B (1 and 2), have been isolated from the roots of Flueggea virosa. Their structures were established by extensive analyses of spectroscopic data. The isolates were evaluated for anti-HCV activity, as well as the inhibition of superoxide anion generation and Elastase release in response to FMLP/cytochalasin B.

Keywords
Anti-HCV; Flueggea virosa; Flueggrene A; Flueggrene B.