New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

  • Nat Prod Bioprospect. 2015 Apr 8;5(2):69-75. doi: 10.1007/s13659-015-0055-5.
Yang Wang  1 ,  Ling Zhang ,  Fang Wang ,  Zheng-Hui Li ,  Ze-Jun Dong ,  Ji-Kai Liu
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
PMID: 25850378 DOI: 10.1007/s13659-015-0055-5
Abstract

One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their Cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

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