The self-assembly of a camptothecin-lysine nanotube

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2834-2838. doi: 10.1016/j.bmcl.2016.04.056.
Yuan Sun  1 ,  Aileen Shieh  1 ,  Se Hye Kim  1 ,  Samantha King  1 ,  Anne Kim  1 ,  Hui-Lung Sun  2 ,  Carlo M Croce  2 ,  Jon R Parquette  1
Affiliations
  • 1. Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
  • 2. Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA.
PMID: 27156772 DOI: 10.1016/j.bmcl.2016.04.056
Abstract

A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against Cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution.

Keywords
Cytotoxicity; Drug delivery; Nanoparticle; Nanotube; Self-assembly.