Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

  • Molecules. 2016 Aug 17;21(8):1075. doi: 10.3390/molecules21081075.
Bing-You Yang  1 ,  Jing Zhang  2 ,  Yan Liu  3 ,  Hai-Xue Kuang  4
Affiliations
  • 1. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China. [email protected].
  • 2. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China. [email protected].
  • 3. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China. [email protected].
  • 4. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China. [email protected].
PMID: 27548119 DOI: 10.3390/molecules21081075
Abstract

Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human Cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively.

Keywords
Asparagaceae; MTT; cytotoxicity; furostanol saponin; spirostanol saponin.
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