Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice

  • Evid Based Complement Alternat Med. 2017;2017:1796209. doi: 10.1155/2017/1796209.
Nancy Sayuri Uchida  1 ,  Saulo Euclides Silva-Filho  1 ,  Gabriel Fernando Esteves Cardia  1 ,  Edivaldo Cremer  1 ,  Francielli Maria de Souza Silva-Comar  1 ,  Expedito Leite Silva  2 ,  Ciomar Aparecida Bersani-Amado  1 ,  Roberto Kenji Nakamura Cuman  1
Affiliations
  • 1. Department of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo 5790, 870020-900 Maringá, PR, Brazil.
  • 2. Department of Chemistry, State University of Maringá, 87020-900 Maringá, PR, Brazil.
PMID: 28717379 DOI: 10.1155/2017/1796209
Abstract

High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), Alkaline Phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis. The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro. Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production. The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment. Citral inhibited neutrophil migration and exhibited antioxidant activity. Our results suggest that citral protects the liver against liver toxicity induced by APAP.

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