1,3,5-Triazines: A promising scaffold for anticancer drugs development

  • Eur J Med Chem. 2017 Dec 15:142:523-549. doi: 10.1016/j.ejmech.2017.09.035.
Stella Cascioferro  1 ,  Barbara Parrino  1 ,  Virginia Spanò  1 ,  Anna Carbone  1 ,  Alessandra Montalbano  1 ,  Paola Barraja  1 ,  Patrizia Diana  1 ,  Girolamo Cirrincione  2
Affiliations
  • 1. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
  • 2. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy. Electronic address: [email protected].
PMID: 29046238 DOI: 10.1016/j.ejmech.2017.09.035
Abstract

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.

Keywords
1,3,5-Triazines; Antitumor activity; Disubstituted 1,3,5-triazines; Heterofused 1,3,5-triazines; Nitrogen heterocycles; Trisubstituted 1,3,5-triazines.