Isosteric ribavirin analogues: Synthesis and antiviral activities

  • Bioorg Med Chem Lett. 2018 Jan 1;28(1):11-14. doi: 10.1016/j.bmcl.2017.11.029.
Nikolay I Zhurilo  1 ,  Mikhail V Chudinov  2 ,  Andrey V Matveev  1 ,  Olga S Smirnova  3 ,  Irina D Konstantinova  3 ,  Anatoly I Miroshnikov  3 ,  Alexander N Prutkov  4 ,  Lyubov E Grebenkina  4 ,  Natalya V Pulkova  4 ,  Vitaly I Shvets  1
Affiliations
  • 1. Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454 Moscow, Russia.
  • 2. Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454 Moscow, Russia. Electronic address: [email protected].
  • 3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russia.
  • 4. Moscow Politechnical University, Bolshaya Semenovskaya Str., 38, 107023 Moscow, Russia.
PMID: 29173944 DOI: 10.1016/j.bmcl.2017.11.029
Abstract

The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant Antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible Antiviral activity mechanism related with bioisosterism.

Keywords
Antivirals; Isosterism; Nucleoside analogues; Ribavirin.