Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

  • Mil Med Res. 2018 Sep 6;5(1):30. doi: 10.1186/s40779-018-0176-3.
Xiao-Rui Zhang  1 ,  Wen-Xia Zhou  2 ,  Yong-Xiang Zhang  3
Affiliations
  • 1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
  • 2. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. [email protected].
  • 3. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. [email protected].
PMID: 30185231 DOI: 10.1186/s40779-018-0176-3
Abstract

AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies.

Keywords
Catalytic antioxidant; Chemical warfare agent; Metalloporphyrins; Pharmacodynamics; Pharmacokinetics; Radiation damage.
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