A new labdane-type diterpenoid from the leaves of Vitex negundo L

  • Nat Prod Res. 2021 Jul;35(14):2329-2334. doi: 10.1080/14786419.2019.1672687.
Jirapast Sichaem  1 ,  Hung-Huy Nguyen  2 ,  Van-Huong Nguyen  3 ,  Dinh-Hung Mac  4 ,  Dinh-Tri Mai  5  6 ,  Hoang-Chuong Nguyen  3 ,  Thi-Ngoc-Mai Tran  7 ,  Nguyen-Kim-Tuyen Pham  8 ,  Huu-Hung Nguyen  9 ,  Nakorn Niamnont  10 ,  Thuc-Huy Duong  11  12
Affiliations
  • 1. Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand.
  • 2. Department of Inorganic Chemistry, University of Science, Ha Noi National University, Ha Noi City, Vietnam.
  • 3. Faculty of Chemistry, University of Education, Ho Chi Minh City, Vietnam.
  • 4. Department of Organic Chemistry, University of Science, Ha Noi National University, Ha Noi City, Vietnam.
  • 5. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
  • 6. Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
  • 7. Institute of Applied Sciences, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Viet Nam.
  • 8. Faculty of Environmental Science, Sai Gon University, Vietnam.
  • 9. Faculty of Biotechnology, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam.
  • 10. Organic Synthesis, Electrochemistry and Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
  • 11. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • 12. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
PMID: 31583894 DOI: 10.1080/14786419.2019.1672687
Abstract

A new labdane-type diterpenoid, named vitexnegundin (1), along with seven known compounds, including vitexilactone (2), vitetrifolin D (3), 13-hydroxy-5(10),14-halimadien-6-one (4), (rel 3S,5S,8R,9R,10S)-3,9-dihydroxy-13(14)-labden-16,15-olide (5), artemetin (6), vitexcarpin (7) and penduletin (8), were isolated from the leaves of Vitex negundo L. Their structures were elucidated by using spectroscopic methods, X-ray crystallographic analysis and comparison with those reported in the literature. Moreover, all isolated compounds 1-8 were evaluated for their antimicrobial activity against ESBL-producing Escherichia coli strain and methicillin-resistant Staphylococcus aureus.

Keywords
Vitex negundo L.; antimicrobial activity; labdane-type diterpenoid; vitexnegundin.
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