High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential

  • Front Cardiovasc Med. 2020 Mar 31:7:39. doi: 10.3389/fcvm.2020.00039.
Anne Jomard  1  2 ,  Elena Osto  1  2  3
Affiliations
  • 1. Laboratory of Translational Nutrition Biology, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
  • 2. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.
  • 3. Department of Cardiology, Heart Center, University Hospital Zurich, Zurich, Switzerland.
PMID: 32296714 DOI: 10.3389/fcvm.2020.00039
Abstract

High Density Lipoproteins (HDLs) have long been considered as "good Cholesterol," beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various Enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.

Keywords
HDL-therapy; bariatric surgery; cardiovascular risk; endothelial function; high density lipoprotein; lipoproteins; obesity.
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