Acylated iridoid glucosides from Pseudocaryopteris paniculata (C.B.Clarke) P.D.Cantino

  • Phytochemistry. 2021 Jan:181:112569. doi: 10.1016/j.phytochem.2020.112569.
Hong-Tao Xu  1 ,  Yi Chen  1 ,  Cheng-Gang Zhang  1 ,  Zheng-Cai Ju  1 ,  Yong-Li Wang  1 ,  Gui-Xin Chou  2
Affiliations
  • 1. The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica (ICMM), Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, People's Republic of China.
  • 2. The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica (ICMM), Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, People's Republic of China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, 201203, People's Republic of China. Electronic address: [email protected].
PMID: 33130374 DOI: 10.1016/j.phytochem.2020.112569
Abstract

Phytochemical investigation of the ethyl acetate fraction of Pseudocaryopteris paniculata C.B.Clarke P.D.Cantino resulted in the identification of 26 undescribed iridoid glucosides (paniculosides A-Z), along with 7 known iridoid glucosides. Their structures were elucidated via two-dimensional nuclear-magnetic-resonance (2D-NMR) spectroscopy, high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS), and chemical-hydrolysis methods. All isolated substances were analyzed for their cytoprotective effects against t-BHP-induced toxicity in HepG2 cells. Among the tested compounds, paniculoside A, paniculoside I, paniculoside T, and paniculoside U exhibited moderate cytoprotective activities with IC50 values in the range of 11.72-34.22 μM against t-BHP-induced toxicity.

Keywords
Cytoprotective activity; Iridoid glucosides; Lamiaceae; NMR spectroscopy; Paniculosides a–Z; Pseudocaryopteris paniculata (C.B.Clarke) P.D.Cantino.
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