Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp

  • J Nat Prod. 2021 Feb 26;84(2):537-543. doi: 10.1021/acs.jnatprod.0c01243.
Xi Xie  1 ,  Shengsheng Lu  1 ,  Xiaoyan Pan  2 ,  Min Zou  1 ,  Fangfang Li  3 ,  Haixing Lin  1 ,  Jianan Hu  1 ,  Sheng Fan  1 ,  Jian He  1
Affiliations
  • 1. Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • 2. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China.
  • 3. Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, China National Analytical Center, Guangzhou 510070, People's Republic of China.
PMID: 33631936 DOI: 10.1021/acs.jnatprod.0c01243
Abstract

A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent Antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.