Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease

  • Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1;320(6):G1034-G1044. doi: 10.1152/ajpgi.00431.2020.
Lu Xu  1 ,  Jingyang Zhou  2 ,  Jinhui Che  1 ,  Haihong Wang  1 ,  Weizhong Yang  1 ,  Wuyuan Zhou  3 ,  Hongying Zhao  4
Affiliations
  • 1. Department of Hepatopancreatobillary Surgery, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
  • 2. Class 182, Queen Mary School, Nanchang University, Nanchang, Jiangxi, China.
  • 3. Department of Hepatopancreatobiliary Surgery, Xuzhou City Cancer Hospital, Gulou District, Xuzhou City, Jiangsu, China.
  • 4. Department of Oncology, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
PMID: 33728991 DOI: 10.1152/ajpgi.00431.2020
Abstract

Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte Pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.

Keywords
AIM2; inflammasome; mitochondrial DNA; nonalcoholic fatty liver disease; oxidative stress.
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