Antiviral Activity of Peptide-Based Assemblies

  • ACS Appl Mater Interfaces. 2021 Oct 20;13(41):48469-48477. doi: 10.1021/acsami.1c16003.
Tan Hu  1  2  3 ,  Omer Agazani  1 ,  Sivan Nir  1 ,  Mor Cohen  1 ,  Siyi Pan  2  3 ,  Meital Reches  1
Affiliations
  • 1. Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  • 2. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China.
  • 3. Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, Ministry of Education, Wuhan, Hubei 430070, P. R. China.
PMID: 34623127 DOI: 10.1021/acsami.1c16003
Abstract

The COVID-19 pandemic highlighted the importance of developing surfaces and coatings with Antiviral activity. Here, we present, for the first time, peptide-based assemblies that can kill viruses. The minimal inhibitory concentration (MIC) of the assemblies is in the range tens of micrograms per milliliter. This value is 2 orders of magnitude smaller than the MIC of metal nanoparticles. When applied on a surface, by drop casting, the peptide spherical assemblies adhere to the surface and form an Antiviral coating against both RNA- and DNA-based viruses including coronavirus. Our results show that the coating reduced the number of T4 bacteriophages (DNA-based virus) by 3 log, compared with an untreated surface and 6 log, when compared with a stock solution. Importantly, we showed that this coating completely inactivated canine coronavirus (RNA-based virus). This peptide-based coating can be useful wherever sterile surfaces are needed to reduce the risk of viral transmission.

Keywords
antiviral coatings; bacteriophage T4; coronavirus; peptides; self-assembly.
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