Anti-inflammatory Dimeric Benzophenones from an Endophytic Pleosporales Species

  • J Nat Prod. 2022 Jan 28;85(1):162-168. doi: 10.1021/acs.jnatprod.1c00900.
Hui-Ting Zeng  1 ,  Yi-Hu Yu  1 ,  Xi Zeng  1 ,  Miao-Miao Li  1 ,  Xia Li  1 ,  Shan-Shan Xu  1 ,  Zong-Cai Tu  2 ,  Tao Yuan  1
Affiliations
  • 1. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi330022, People's Republic of China.
  • 2. College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi330022, People's Republic of China.
PMID: 35007071 DOI: 10.1021/acs.jnatprod.1c00900
Abstract

Eight new polyketides, including three dimeric benzophenones, named dipleosporones A-C (1-3), three benzophenones (4-6), one xanthone (7), and one phenylbenzoate (8), along with seven known polyketides (9-15) were isolated from the fungus Pleosporales sp. YY-4. The structures of the new compounds were established on the basis of spectroscopic methods, including high-resolution electrospray ionization mass spectrometry and one- and two-dimensional nuclear magnetic resonance. This is the first report of a benzophenone dimer connection via a C bridge from natural sources. An anti-inflammatory assay indicated that the dimeric benzophenones (1-3) inhibited lipopolysaccharide-induced NO production in RAW 264.7 cells, with half-maximal inhibitory concentration (IC50) values ranging from 8.8 to 18.1 μM, being more potent than the positive control, dexamethasone (IC50 = 22.2 μM).