Cychlorphine (N-Propionitrile Chlorphine): An Emerging Benzimidazolone Synthetic Opioid and Its Implications for Overdose Recognition and Management

  • J Pain Res. 2026 Jul 10:19:620907. doi: 10.2147/JPR.S620907.
Robert B Raffa  1  2 ,  Frank Breve  3 ,  Joseph V Pergolizzi Jr  2  4 ,  Eugene Vortsman  5 ,  Giustino Varrassi  6
Affiliations
  • 1. School of Pharmacy, Temple University (Emeritus), Philadelphia, PA, USA.
  • 2. Research and Development, Enalare Therapeutics, Mullica Hill, NJ, USA.
  • 3. Clinical Pharmacy, Mid Atlantic PharmaTech Consultants, Ventnor City, NJ, USA.
  • 4. Anesthesiology, NEMA Research, Naples, FL, USA.
  • 5. Emergency Department, Long Island Jewish Medical Center at Northwell Health, New York, NY, USA.
  • 6. VIBRO, Fondazione Paolo Procacci, Roma, Italy.
PMID: 42454006 DOI: 10.2147/JPR.S620907
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