Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

  • J Antibiot (Tokyo). 1994 Feb;47(2):154-62. doi: 10.7164/antibiotics.47.154.
Y K Kim  1 ,  H Tomoda ,  H Nishida ,  T Sunazuka ,  R Obata ,  S Omura
Affiliations
  • 1. Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 8150710 DOI: 10.7164/antibiotics.47.154
Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol Acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

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