Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

  • Science. 1977 Apr 15;196(4287):326-8. doi: 10.1126/science.847477.
D R Burt ,  I Creese ,  S H Snyder
PMID: 847477 DOI: 10.1126/science.847477
Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal Dopamine Receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to Dopamine Receptor stimulants in such Animals and for tardive dyskinesia in patients treated with these drugs.

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