1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB 271046

SB 271046 

Cat. No.: HY-14336
Handling Instructions

SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity.

For research use only. We do not sell to patients.

SB 271046 Chemical Structure

SB 271046 Chemical Structure

CAS No. : 209481-20-9

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Description

SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1].

IC50 & Target[1]

5-HT6 Receptor

8.92-9.09 (pKi)

In Vitro

In functional studies on human 5-HT6 receptors SB 271046 competitively antagonized 5-HT-induced stimulation of adenylyl cyclase activity with a pA2 of 8.71[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ⩽0.1 mg/kg p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50 of 0.16 μM) and brain concentrations of 0.01-0.04 μM at Cmax[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

451.99

Formula

C20H22ClN3O3S2

CAS No.
SMILES

O=S(NC1=CC=C(C(N2CCNCC2)=C1)OC)(C3=C(C)C4=C(C=CC(Cl)=C4)S3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SB 271046
Cat. No.:
HY-14336
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