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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
54 Results for "
N-RAS
" in MedChemExpress (MCE) Product Catalog:
Products (54)
54 Results for "N-RAS" in MCE Product Catalog:
Cat. No.: HY-110038
CAS No.: 1217447-06-7
Research Areas:
FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .
Cat. No.: HY-116428
CAS No.: 160141-09-3
Research Areas:
L-744832 is a farnesyl transferase inhibitor. L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras, but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis. L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .
Cat. No.: HY-RS09559
Target:
Research Areas:
Nras Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09558
Target:
Research Areas:
NRAS Human Pre-designed siRNA Set A contains three designed siRNAs for NRAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163515
Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity .
Cat. No.: HY-117893
CAS No.: 201487-53-8
Target:
Research Areas:
BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC50 = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer .
Cat. No.: HY-W1126467
CAS No.: 3061844-70-7
RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer .
Cat. No.: HY-176343S
Cat. No.: HY-RS09560
Target:
Research Areas:
Nras Rat Pre-designed siRNA Set A contains three designed siRNAs for Nras gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P73741A
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: NRAS; Proto-Oncogene GTPase; NRAS Proto-Oncogene, GTPase; N-RAS Protein Part 4; N-RAS; ALPS4; Neuroblastoma RAS Viral (V-RAS) Oncogene Homolog; NRAS1; Neuroblastoma RAS Viral Oncogene Homolog; HRAS1; Transforming Protein N-RAS; CMNS; GTPase NRAS; NCMS; V-
Cat. No.: HY-P73741
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRAS; Proto-Oncogene GTPase; NRAS Proto-Oncogene, GTPase; N-RAS Protein Part 4; N-RAS; ALPS4; Neuroblastoma RAS Viral (V-RAS) Oncogene Homolog; NRAS1; Neuroblastoma RAS Viral Oncogene Homolog; HRAS1; Transforming Protein N-RAS; CMNS; GTPase NRAS; NCMS; V-
Cat. No.: HY-149705
CAS No.: 1313603-21-2
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
Cat. No.: HY-101641
CAS No.: 204718-47-8
Research Areas:
NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
