3061844-70-7
Chemical Structure
RAS-IN-5
- CAS No.: 3061844-70-7
- Formula:C57H72N5O9P
- Molecular Weight:1002.18
InChIKey: XGOMGYWSGGHTOA-AFZZAKQYSA-N
SMILES: O=C(N1CCC[C@@H](C(OCC(C)(C)CC2=C(C3=C([C@H](C)OC)C=CC(P(C)(C)=O)=C3)N(CC)C4=C2C=C5C=C4)=O)N1)[C@@H](NC([C@H](C(C)C)N(C)C([C@H]6[C@@H](C7=CC=CC=C7)CCO6)=O)=O)CC8=CC(O)=CC5=C8
Biological Activity: RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer[1].
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RAS-IN-5 | RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer. | |||||||||||||||||||||
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