3061844-70-7
Chemical Structure
RAS-IN-5
- CAS No.: 3061844-70-7
- Formula:C57H72N5O9P
- Molecular Weight:1002.18
InChIKey: XGOMGYWSGGHTOA-AFZZAKQYSA-N
SMILES: CCN1C2=C3C=C(C4=CC(C[C@@H](C(N5CCC[C@@H](C(OCC(C)(CC3=C1C6=C(C=CC(P(C)(C)=O)=C6)[C@@H](OC)C)C)=O)N5)=O)NC([C@@H](N(C([C@@H]7OCC[C@@H]7C8=CC=CC=C8)=O)C)C(C)C)=O)=CC(O)=C4)C=C2
Biological Activity: RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer[1].
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RAS-IN-5 | RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
