204718-47-8
204718-47-8
Chemical Structure
NRA-0160
- CAS No.: 204718-47-8
- Formula:C24H23F2N3OS
- Molecular Weight:439.52
IUPAC Name: 5-(2-(4-(3-fluorobenzylidene)piperidin-1-yl)ethyl)-4-(4-fluorophenyl)thiazole-2-carboxamide
InChIKey: QESXTNJNPLVEOR-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2=CC=C(F)C=C2)=C(CCN3CC/C(CC3)=C\C4=CC=CC(F)=C4)S1)N
Biological Activity: NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
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NRA-0160 | NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM). | |||||||||||||||||||||
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