5335-97-7
5335-97-7
Chemical Structure
NSC1011
- CAS No.: 5335-97-7
- Formula:C23H18N2O3
- Molecular Weight:370.40
IUPAC Name: 4-(((8-hydroxyquinolin-7-yl)(phenyl)methyl)amino)benzoic acid
InChIKey: PSCFZETTYRDCRM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
Biological Activity: NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1].
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NSC1011 | NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras. | |||||||||||||||||||||
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References
Keywords
