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Cat. No.: HY-122079

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NSC1011

NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC₅₀ value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras.

For research use only. We do not sell to patients.

CAS No.: 5335-97-7
Formula: C₂₃H₁₈N₂O₃
Molecular Weight:370.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NSC1011 Chemical Structure

CAS No.: 5335-97-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 6.9 µM (Rce1)^[1]

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U-87MG ATCC	IC₅₀	>10 μM Compound: NC269, NSC 1011	Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay	[PMID: 32830969]

In Vitro

NSC1011 (25 µM; 20 h) induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras in HCT-116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 5335-97-7
Molecular Weight 370.40
Formula C₂₃H₁₈N₂O₃
SMILES

O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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