NSC1011
NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras.
For research use only. We do not sell to patients.
- CAS No.: 5335-97-7
- Formula: C23H18N2O3
- Molecular Weight:370.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 6.9 µM (Rce1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
>10 μM
Compound: NC269, NSC 1011
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Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 32830969] |
NSC1011 (25 µM; 20 h) induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5335-97-7
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Molecular Weight 370.40
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Formula C23H18N2O3
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SMILES
O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC1011 Related Classifications
HY-122079 Related Classifications
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