1 Result for "

LCAS disodium

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "LCAS disodium" in MCE Product Catalog:

Cat. No.: HY-113238A
CAS No.: 64936-81-8
Purity:  99.93%
Synonyms: Sulfolithocholic acid disodium; LCAS disodium
Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+, and 0.88 μM and 0.97 μM in the presence of Zn 2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .
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