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1036734-93-6

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "1036734-93-6" in MCE Product Catalog:

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Cat. No.: HY-P99165
CAS No.: 1036734-93-6

Target:  

IGF-1R TSH Receptor

Research Areas:  

Endocrinology

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .
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