1 Result for "

1946-74-3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "1946-74-3" in MCE Product Catalog:

α-Thujaplicin
α-Thujaplicin
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Cat. No.: HY-N15140
CAS No.: 1946-74-3
Category:  

Natural Products Cupressaceae Ketones, Aldehydes, Acids Plants Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.

Target:  

Drug Isomer Bacterial Fungal Carboxypeptidase

α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
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