1 Result for "

2295804-68-9

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "2295804-68-9" in MCE Product Catalog:

Cat. No.: HY-151481
CAS No.: 2295804-68-9
Purity:  98.01%
Target:  

FXR

Research Areas:  

Metabolic Disease

FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies .
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