2295804-68-9
Chemical Structure
FXR antagonist 1
- CAS No.: 2295804-68-9
- Formula:C36H59NO5
- Molecular Weight:585.86
IUPAC Name: ((1S,3aS,5aR,5bR,7aR,9R,11aR,11bR,13aR,13bR)-9-(butyryloxy)-1-isopropyl-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysene-3a-carbonyl)glycine
InChIKey: CLKCLHBPLVDIOB-VCXUAKCGSA-N
SMILES: OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@@H](CC5)OC(CCC)=O)C)([H])CC4)C)([H])CC3)C)C)=O)=O
Biological Activity: FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies[1].
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FXR antagonist 1 | 99.85% | FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies. | ||||||||||||||||||||
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Keywords
