β-FXR antagonist 1
Based on 1 Customer Validation
β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 2295804-92-9
- Formula: C36H59NO5
- Molecular Weight:585.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Obesity Compound Library
HY-L087
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Nuclear Receptor Compound Library
HY-L126
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Fibrosis Compound Library
HY-L185
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
>100 μM
Compound: F17
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Cytotoxicity against HEK293T cells cotransfected with pCMV-Script-hFXR/pGL4.11-hSHP-Luciferase incubated for 24 hrs in presence of GW4064 by celltiter-blue cell viability assay
Cytotoxicity against HEK293T cells cotransfected with pCMV-Script-hFXR/pGL4.11-hSHP-Luciferase incubated for 24 hrs in presence of GW4064 by celltiter-blue cell viability assay
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[PMID: 36107013] |
Chemical Information
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CAS No. 2295804-92-9
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Appearance Solid
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Molecular Weight 585.86
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Formula C36H59NO5
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Color White to off-white
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SMILES
OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)OC(CCC)=O)C)([H])CC4)C)([H])CC3)C)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (170.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7069 mL | 8.5345 mL | 17.0689 mL | 42.6723 mL |
| 5 mM | 0.3414 mL | 1.7069 mL | 3.4138 mL | 8.5345 mL | |
| 10 mM | 0.1707 mL | 0.8534 mL | 1.7069 mL | 4.2672 mL | |
| 15 mM | 0.1138 mL | 0.5690 mL | 1.1379 mL | 2.8448 mL | |
| 20 mM | 0.0853 mL | 0.4267 mL | 0.8534 mL | 2.1336 mL | |
| 25 mM | 0.0683 mL | 0.3414 mL | 0.6828 mL | 1.7069 mL | |
| 30 mM | 0.0569 mL | 0.2845 mL | 0.5690 mL | 1.4224 mL | |
| 40 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 1.0668 mL | |
| 50 mM | 0.0341 mL | 0.1707 mL | 0.3414 mL | 0.8534 mL | |
| 60 mM | 0.0284 mL | 0.1422 mL | 0.2845 mL | 0.7112 mL | |
| 80 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5334 mL | |
| 100 mM | 0.0171 mL | 0.0853 mL | 0.1707 mL | 0.4267 mL |
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