RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent betulinic acid derivative, is an antagonist of RORγ (KD=0.18 μM). RORγ antagonist 1 exhibits anti-proliferative activity in HPAF-II pancreatic cancer xenograft model. RORγ antagonist 1 inhibits RAS/MAPK and AKT/mTORC1 pathway, and induces caspase-dependent apoptosis in pancreatic cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 3049676-15-2
- Formula: C35H60N2O2
- Molecular Weight:540.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RORγ[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HPAF-II | IC50 |
0.09 μM
Compound: 22
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Antitumor activity against human HPAF-II cells measured after 72 hrs
Antitumor activity against human HPAF-II cells measured after 72 hrs
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[PMID: 37236000] |
Chemical Information
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CAS No. 3049676-15-2
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Molecular Weight 540.86
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Formula C35H60N2O2
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SMILES
O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C(NCCCN(C)C)=O)[C@]4([H])[C@H](C(C)=C)CC5)([H])C1(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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