1 Result for "

3033697-19-4

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3033697-19-4" in MCE Product Catalog:

Cat. No.: HY-182103
CAS No.: 3033697-19-4
Target:  

MAP3K Caspase p38 MAPK

Research Areas:  

Cardiovascular Disease

ZAK-IN-2 (Compound 8) is a selective, covalent ZAK inhibitor with an IC50 of 11.5 nM. ZAK-IN-2 forms a covalent bond with Cys22 in the P-loop of ZAK to inhibit its kinase activity. ZAK-IN-2 inhibits the phosphorylation of the downstream target p38. ZAK-IN-2 blocks Doxorubicin (HY-15142A)-induced cleavage of Caspase 3. ZAK-IN-2 is applicable to research related to myocardial hypertrophy .
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