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3046451-91-3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3046451-91-3" in MCE Product Catalog:

Cat. No.: HY-149079
CAS No.: 3046451-91-3
Target:  

Parasite Necroptosis

Research Areas:  

Infection

Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
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